Molecular basis of hematological malignancies: a focus on leukemia and lymphoma
Wednesday 6 July 2022 (9:00-17:30)
The objective of this symposium is to bring together renowned scientists working on leukemia and hematopoietic/leukemic stem cells. In particular, it will discuss the latest discoveries and strategies in leukemia research, diagnosis and treatments. In addition, this symposium aims to build networks and collaborations among international scientists, especially French and Lebanese researchers. The event will allow researchers to exchange ideas relevant to the MUSE/MAK’IT ‘Protect’ and ‘Care’ challenges, related to the health of cancer leukemia patients.
The topics will range from understanding the influence of bone marrow microenvironment in normal and leukemic stem cells as well as intercellular communication and RNA signaling within the niche. Speakers will also discuss mutations in pre-leukemic hematopoietic stem cells and AML cells (Nucleophosmin-1) and novel strategies to target Adult T cell leukemia, T-cell ALL, B cell malignancies, and Childhood Leukemia.
Programme and speakers
9:00 – 9:15 Kazem ZIBARA, Libanese University, Lebanon & MAK’IT Fellow (IGH/IGMM), France
Introduction
9:15 – 9:45 Dominique BONNET, Francis Crick Institute, the UK
‘Dissecting the cross-talk between normal, leukaemic stem cells and the bone marrow microenvironment’
9:45 – 10:15 Haidar AKL, Libanese University, Lebanon
‘Calcium mediated cell fate dysregulation: A perspective on cancer’
10:15 – 10:45 Marwan EL-SABBAN,American University of Beirut, Lebanon
‘Intercellular Communication in hematological Malignancies’
10:45 – 11:00 COFFEE BREAK
11:00 – 11:30 Akram GHANTOUS, International Agency for Research on Cancer, France
‘Search for Origins of Childhood Leukemia: Mapping “Molecular Diary” of Nature and Nurture’
11:30 – 12:00 Hiba EL-HAJJ, American University of Beirut, Lebanon
‘Nucleophosmin-1 in Acute Myeloid Leukemia: A friend or a foe?’
12:00 – 14:00 LUNCH
14:00 – 14:30 Kolja EPPERT, McGill University, Canada
‘Characterizing the role of oncogenic mutations in pre-leukemic hematopoietic stem cells’
14:30 – 15:00 Youmna KFOURY, Moderna, USA
‘RNA signaling in the bone marrow microenvironment’
15:00 –15:30 Amy SEXAUER, Harvard Medical School & Massachusetts Institute of Technology, USA
‘Defining the role of DHODH inhibition in the treatment of T-cell ALL’
15:30 – 15:50 COFFEE BREAK
15:50 – 16:20 Jérôme MOREAUX, Institute of Human Genetics, Montpellier, France
‘Targeting cellular iron homeostasis in B cell malignancies’
16:20 – 16:50 Ali BAZARBACHI, American University of Beirut, Lebanon
‘Adult T cell leukemia as a virus addicted malignancy: implications for therapy’
16:50 – 17:20 Ludovic GABELLIER, Institute of Molecular Genetics of Montpellier, France
‘Targeting SUMOylation in preclinical models of AML’
17:20 – 17:30 Conclusion